Benzodiazepines

We have a list of Benzodiazepines like Alprazolam, Etizolam or Flubromazolam for anxiety, depression, alcohol withdrawal and laboratory research and analytical applications from trusted RC shop — NNRCHEM with overnight shipping in USA, Canada and EU. No “customs” or “hidden fees”.

Benzodiazepines and their modern designer variants form one of the most widely prescribed and simultaneously most frequently encountered classes of psychoactive substances in clinical, forensic, and toxicological practice. All materials in this category are supplied exclusively as high-purity analytical reference standards for use in accredited forensic, clinical, pharmaceutical, and academic laboratories.

What are benzodiazepines?

Benzodiazepines are a class of compounds characterized by a fused benzene and diazepine ring system (1,4-benzodiazepine core). They act primarily as positive allosteric modulators of the GABA_A receptor, enhancing the inhibitory effects of γ-aminobutyric acid (GABA) in the central nervous system.

The classic pharmaceutical benzodiazepines were developed between the 1960s and 1990s for the treatment of anxiety, insomnia, seizures, muscle spasms, and alcohol withdrawal. Designer benzodiazepines (also called “novel benzodiazepines” or “research benzodiazepines”) are structurally related compounds that have appeared on the recreational market or in gray-area sales since approximately 2010, often with minor modifications to the core structure to evade existing scheduling.

Major structural families

Classic 1,4-benzodiazepines (pharmaceutical origin)

• Diazepam
• Nordazepam (nordiazepam)
• Oxazepam
• Temazepam
• Lorazepam
• Alprazolam
• Clonazepam
• Bromazepam
• Midazolam
• Flunitrazepam
• Nitrazepam
• Clobazam
• Chlordiazepoxide

Triazolobenzodiazepines (fused triazole ring)

• Alprazolam
• Triazolam
• Estazolam
• Flubromazolam (designer variant but triazolo structure)
• Clonazolam
• Flualprazolam

Common designer / novel benzodiazepines

• Halogenated & alkylated variants
  • Flubromazolam
  • Flualprazolam
  • Clonazolam
  • Flubromazepam
  • Bromazolam
  • Pyrazolam
  • Fluclotizolam
  • Etizolam (thienodiazepine, not true benzodiazepine but functionally similar)
  • Deschloroetizolam
  • Metizolam
• Nitro-substituted & other variants
  • Flunitrazolam
  • Clonitrazolam
  • Nitrazolam
  • Nifoxipam
  • Meclonazepam
• Other structural relatives
  • Phenazepam
  • 3-Hydroxyphenazepam
  • Cinazepam
  • Gidazepam (prodrug to desalkylgidazepam)
  • Adinazolam
  • Delorazepam
  • Lormetazepam
  • Tetrazepam (withdrawn in many countries)

Legitimate scientific and analytical applications

Certified reference standards of benzodiazepines and designer variants are essential for:

• Development and validation of LC-MS/MS and HRMS multi-analyte methods for screening and confirmation
• Detection and quantification in clinical toxicology, post-mortem toxicology, drug-facilitated crime cases, and workplace testing
• Analysis of biological matrices (whole blood, serum/plasma, urine, oral fluid, hair, vitreous humor)
• Metabolic profiling (many benzodiazepines produce active metabolites with long detection windows)
• Pharmacokinetic and pharmacodynamic studies
• Preparation of calibrators, quality control samples, and proficiency testing materials
• Stability studies (especially important for triazolo- and designer compounds in solution)
• Support for drug-checking programs and harm-reduction initiatives

Regulatory status and compliance requirements

Most classic benzodiazepines are controlled prescription medications, while many designer variants are now explicitly scheduled:

• United States — Schedule IV (most pharmaceutical benzodiazepines); many designer variants Schedule I (clonazolam, flualprazolam, flubromazolam, etc.) via analogue act or emergency scheduling
• Canada — Schedule IV or I depending on compound
• European Union — prescription-only for pharmaceuticals; most novel benzodiazepines are now controlled under national NPS laws or EU-wide measures
• United Kingdom — Class C (most benzodiazepines); several designer variants Class B or A
• Australia, Japan, China, Russia — strictly controlled or prohibited

All products are supplied strictly for research, forensic, toxicological, and analytical purposes only. They are not intended for human or veterinary consumption, diagnostic use, therapeutic use, or any form of in-vivo administration. Customers must hold all required licenses, permits, and authorizations under applicable controlled substances and pharmaceutical regulations.

Quality standards for benzodiazepine reference materials

Reputable suppliers provide:

• Purity ≥98–99.9% (HPLC, qNMR)
• Full certificate of analysis including identity (NMR, HRMS, UV, IR), purity, and batch-specific data
• Isotopically labeled internal standards (e.g., diazepam-d₅, alprazolam-d₅, clonazepam-d₄, etizolam-d₃, flubromazolam-d₄)
• Documentation of positional isomer purity and absence of common contaminants
• Recommended storage conditions (typically −20°C or −80°C, protected from light and moisture)
• Stability data for parent compounds and major metabolites

Commonly requested benzodiazepines & designer variants in analytical laboratories

• Diazepam
• Nordazepam
• Oxazepam
• Temazepam
• Lorazepam
• Alprazolam
• Clonazepam
• Etizolam
• Flubromazolam
• Bromazolam
• Flualprazolam
• Clonazolam
• Pyrazolam
• Fluclotizolam
• Phenazepam
• Delorazepam
• Meclonazepam
• Flunitrazolam

Benzodiazepines and their designer variants remain among the most frequently detected classes of psychoactive substances in clinical, forensic, and post-mortem toxicology worldwide. High-quality, well-characterized analytical reference standards are indispensable for accurate identification, precise quantification, long-window metabolite detection, method validation, and supporting public health, law enforcement, and clinical decision-making.

All materials in this category are provided exclusively for legitimate research and analytical purposes and must be handled in strict compliance with national and international controlled substances regulations.

Explore individual product pages for detailed specifications, certificates of analysis, safety data sheets, and current availability of each benzodiazepine reference standard.