Opioids

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Fentanyl analogs and related synthetic opioids represent one of the most potent and structurally diverse classes of compounds currently encountered in forensic toxicology, clinical chemistry, and pharmaceutical research. All materials in this category are supplied exclusively as high-purity analytical reference standards for use in accredited laboratories.

What are fentanyl analogs and synthetic opioids?

Fentanyl is a synthetic 4-anilidopiperidine derivative originally developed as a potent opioid analgesic. Its chemical structure allows for extensive modification while retaining — and often dramatically increasing — μ-opioid receptor agonist activity.

Fentanyl analogs (also called fentanyl-related substances) are compounds that share structural features with fentanyl, particularly the 4-anilidopiperidine core, but differ in substituents on the piperidine ring, the aniline nitrogen, the propionyl group, or other positions.

The broader category of synthetic opioids also includes structurally distinct classes that are not fentanyl derivatives but exhibit significant opioid activity.

Major structural families of fentanyl analogs

• 4-Anilidopiperidines (classic fentanyl scaffold)
  • Fentanyl
  • Alfentanil
  • Sufentanil
  • Remifentanil
  • Carfentanil
  • Lofentanil
• N-Substituted fentanyl analogs (most common in forensic casework)
  • Acetylfentanyl
  • Acrylfentanyl
  • Butyrylfentanyl
  • Crotonylfentanyl
  • Furanylfentanyl
  • Isobutyrylfentanyl
  • Valerylfentanyl
  • 4-Fluoroisobutyrylfentanyl (4F-iBF)
  • 4-Fluorobutyrylfentanyl (4F-BF)
  • Ortho-fluorofentanyl
  • Para-fluorofentanyl
  • Meta-fluorofentanyl
• Benzyl- and phenethyl-substituted analogs
  • Benzylfentanyl
  • 3-Methylbenzylfentanyl
  • β-Hydroxythiofentanyl
  • Thienylfentanyl
• Cyclohexyl- and other ring-substituted analogs
  • Cyclopropylfentanyl
  • Tetrahydrofuranylfentanyl (THF-F)
  • Methoxyacetylfentanyl (MAF)
• Piperidine ring-modified analogs
  • 3-Methylfentanyl
  • α-Methylfentanyl
  • 3,3-Dimethylfentanyl
  • Isotonitazene (2-benzyl-5-nitro-1-(2-(diethylamino)ethyl)benzimidazole) — structurally distinct but extremely potent

Other synthetic opioids (non-fentanyl derived)

• Benzimidazoles / nitazenes
  • Isotonitazene
  • Metonitazene
  • Protonitazene
  • Etazene
  • N-Desethylisotonitazene
• Piperazines & related
  • MT-45
  • Dipyanone
• Ureas & others
  • AH-7921
  • U-47700
  • U-48800
  • U-49900

Legitimate scientific and analytical applications

High-purity reference standards of fentanyl analogs and other synthetic opioids are essential for:

• Development and validation of highly sensitive targeted and untargeted LC-MS/MS and HRMS methods
• Confirmation and quantification in seized drug material (powders, tablets, blotters, liquids, patches, nasal sprays)
• Post-mortem and clinical toxicology in blood, serum, plasma, urine, oral fluid, hair, vitreous humor, and tissues
• Metabolic profiling and identification of phase I and II metabolites
• Pharmacokinetic and pharmacodynamic studies
• Preparation of calibrators, quality control samples, and proficiency testing materials
• Stability studies under various storage and matrix conditions
• Support for drug-checking programs and harm-reduction analytical workflows

Regulatory status and compliance requirements

Virtually all fentanyl analogs and potent synthetic opioids are controlled substances in most jurisdictions:

• United States — Schedule I (most fentanyl analogs, nitazenes, U-47700, etc.) or Schedule II (pharmaceutical fentanyl, sufentanil, alfentanil, remifentanil)
• Canada — Schedule I
• European Union — controlled under national laws and EU NPS framework; many analogs are explicitly listed or covered by generic definitions
• United Kingdom — Class A
• Australia, Japan, China, Russia, South Korea — prohibited or strictly controlled

All products are supplied strictly for research, forensic, toxicological, and analytical purposes only. They are not intended for human or veterinary consumption, diagnostic use, therapeutic use, or any form of in-vivo administration. Customers must possess all required licenses, permits, DEA registrations (or equivalent), and authorizations mandated by national and international controlled substances regulations.

Quality standards for opioid reference materials

Reputable suppliers provide:

• Purity ≥98–99.9% (HPLC, qNMR)
• Full certificate of analysis including identity (NMR, HRMS, IR, UV), purity, and batch-specific data
• Isotopically labeled internal standards (e.g., fentanyl-d₅, norfentanyl-d₃, 4-ANPP-d₅, U-47700-d₆, isotonitazene-d₃)
• Documentation of positional and regioisomer purity (critical for ortho/meta/para-fluorofentanyl, etc.)
• Recommended storage conditions (usually −20°C or −80°C, light and moisture protected)
• Stability data for parent compounds and major metabolites

Commonly requested compounds in modern analytical laboratories

• Fentanyl
• Norfentanyl (major metabolite)
• 4-ANPP (precursor)
• Acetylfentanyl
• Acrylfentanyl
• Furanylfentanyl
• Carfentanil
• Isotonitazene
• Metonitazene
• Protonitazene
• U-47700
• AH-7921
• Cyclopropylfentanyl
• 4-Fluoroisobutyrylfentanyl (4F-iBF)
• Butyrylfentanyl

Fentanyl analogs and other synthetic opioids represent one of the most potent, rapidly evolving, and analytically demanding classes of substances in contemporary forensic and clinical toxicology. Certified reference standards of these compounds are indispensable for accurate identification, precise quantification, metabolite characterization, method validation, and supporting public health and law enforcement efforts worldwide.

All materials are provided exclusively for legitimate research and analytical purposes and must be handled in strict compliance with national and international controlled substances regulations.

Explore individual product pages for detailed specifications, certificates of analysis, safety data sheets, and current availability of each reference standard.