Lysergamides

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Lysergamides represent a structurally distinct class of compounds derived from or structurally related to lysergic acid, the core molecule found in ergot alkaloids. These substances are supplied exclusively as high-purity analytical reference standards for use in forensic, clinical, toxicological, pharmaceutical, and academic research laboratories worldwide.

What are lysergamides?

Lysergamides are characterized by the presence of a tetracyclic ergoline ring system consisting of an indole nucleus fused to a quinoline moiety, with a carboxamide group typically at position 8. The parent compound, lysergic acid diethylamide (LSD), is the most well-known member of this class and has been extensively studied since its discovery in 1938.

All lysergamides share the same core ergoline structure but differ in substituents at the amide nitrogen (R-group) and occasionally at other positions on the ring system. These structural modifications significantly alter receptor binding profiles, potency, duration of action, and metabolic pathways.

Historical and chemical context

The lysergamide class originated from research on ergot alkaloids produced by the fungus Claviceps purpurea. Semi-synthetic derivatives were developed throughout the mid-20th century to investigate structure-activity relationships at serotonin receptors, particularly the 5-HT₂A subtype.

Modern lysergamides of analytical interest are typically produced via total or semi-synthesis and include both historically significant compounds and newer research chemicals that have appeared in forensic casework.

Major structural categories and representative compounds

Lysergamides are generally classified by their N-substituents:

• N,N-Dialkyl lysergamides
  • Lysergic acid diethylamide (LSD, LSD-25)
  • Lysergic acid dimethylamide (DAM-57)
  • Lysergic acid diisopropylamide (LSDiPr, not commonly encountered)
• N-Monoalkyl lysergamides
  • Lysergic acid methylpropylamide (LAMPA)
  • Lysergic acid morpholide (LSM-775)
• N-Acyl lysergamides (typically inactive as prodrugs or metabolites)
  • Lysergic acid amide (LSA, ergine – naturally occurring in morning glory and Hawaiian baby woodrose seeds)
  • Iso-lysergic acid amide (iso-LSA)
• 1-Position modified lysergamides (newer designer/research compounds)
  • 1P-LSD (1-propionyl-lysergic acid diethylamide)
  • 1cP-LSD (1-cyclopropionyl-lysergic acid diethylamide)
  • 1V-LSD (1-valeroyl-lysergic acid diethylamide)
  • 1B-LSD (1-butanoyl-lysergic acid diethylamide)
  • 1P-AL-LAD (1-propionyl-6-allyl-6-norlysergic acid diethylamide)
  • 1P-ETH-LAD (1-propionyl-6-ethyl-6-norlysergic acid diethylamide)
• 6-Alkyl-6-norlysergamides (AL-LAD and ETH-LAD series)
  • AL-LAD (6-allyl-6-norlysergic acid diethylamide)
  • ETH-LAD (6-ethyl-6-norlysergic acid diethylamide)
  • PRO-LAD (6-propyl-6-norlysergic acid diethylamide)

Legitimate scientific and analytical applications

Certified reference materials of lysergamides and their metabolites are essential in the following areas:

• Development and validation of highly sensitive LC-MS/MS and HRMS screening methods
• Confirmation of identity in seized materials (blotters, liquids, powders, tablets)
• Quantitative analysis in biological matrices (whole blood, serum, urine, oral fluid, hair)
• Pharmacokinetic and pharmacodynamic studies
• Receptor binding and functional assays (5-HT₂A, 5-HT₂B, 5-HT₂C, dopamine D₂, etc.)
• Metabolic profiling and identification of phase I/II metabolites
• Stability testing under various storage conditions
• Preparation of calibrators and quality control samples for proficiency testing

Regulatory status and compliance requirements

Virtually all psychoactive lysergamides are strictly controlled internationally:

• United States — LSD and most analogs are Schedule I (DEA)
• Canada — Schedule III (CDSA)
• European Union — Controlled under national implementations of the 1971 UN Convention; many newer 1-acyl derivatives fall under the EU “new psychoactive substances” framework or national analog/generic legislation
• United Kingdom — Class A (Misuse of Drugs Act) with broad generic coverage
• Australia, Japan, and most other countries — similar prohibitive scheduling

All products in this category are supplied strictly for research, forensic, and analytical purposes only. They are not for human consumption, diagnostic, therapeutic, or in-vivo use of any kind. Customers must possess all required licenses, permits, and authorizations under applicable controlled substances legislation.

Quality standards for lysergamide reference materials

Reputable suppliers provide:

• Purity ≥98.5–99.9% (HPLC, qNMR)
• Full spectroscopic characterization (¹H-NMR, ¹³C-NMR, HRMS, UV)
• Certificate of Analysis with batch-specific data
• Isotopically labeled internal standards (e.g., LSD-d₃, LSD-d₁₀)
• Documentation of stereochemistry (all natural-configuration lysergamides are 5R,8R unless otherwise stated)
• Long-term stability data under recommended storage conditions (−20°C or −80°C, protected from light and moisture)

Commonly requested lysergamides in modern analytical laboratories

• LSD (lysergic acid diethylamide)
• iso-LSD (inactive epimer, common impurity/degradant)
• 1P-LSD
• 1cP-LSD
• 1V-LSD
• 1B-LSD
• AL-LAD
• ETH-LAD
• 1P-ETH-LAD
• LAMPA
• LSM-775
• Nor-LSD (metabolite)
• 2-Oxo-3-hydroxy-LSD (major urinary metabolite)

Lysergamides remain one of the most pharmacologically potent and analytically challenging classes of substances encountered in forensic and clinical toxicology. High-quality, fully characterized reference standards are indispensable for accurate identification, reliable quantification, and advancing scientific understanding of this unique chemical family.

All materials are provided exclusively for legitimate research and analytical purposes and must be handled in strict accordance with national and international controlled substances regulations.

Explore the individual product listings for detailed specifications, certificates of analysis, safety data sheets, and current availability of each lysergamide reference standard.