Amphetamines

We have a list of Amphetamines Research Chemicals like 2-FMA, or 3-FMA for Laboratory Analytical Applications and for ADHD, Depression, Anxiety, Weight loss and Chronic Pain from our trusted RC shop — NNRCHEM with overnight shipping in USA, Canada and EU. No “customs” or “hidden fees”.

Amphetamines are a major class of synthetic central nervous system stimulants structurally based on α-methylphenethylamine. They remain among the most frequently encountered substances in forensic toxicology, clinical testing, workplace drug screening, and pharmaceutical quality control. All materials in this category are supplied exclusively as high-purity analytical reference standards for use in accredited laboratories.

What are amphetamines?

The core structure is α-methylphenethylamine (amphetamine), consisting of a phenyl ring attached to an ethylamine chain with a methyl group on the α-carbon. This α-methyl substitution increases metabolic stability and central nervous system activity compared to the parent phenethylamine.

Amphetamines primarily act by promoting the release and inhibiting the reuptake of monoamine neurotransmitters (dopamine, norepinephrine, and to a lesser extent serotonin) via interaction with the corresponding transporters (DAT, NET, SERT).

The class includes both pharmaceutical agents and a wide range of illicit/synthetic analogs.

Major structural families

Classic / pharmaceutical amphetamines

• Amphetamine (racemic and enantiopure d-amphetamine)
• Methamphetamine (N-methylamphetamine)
• Lisdexamfetamine (prodrug of d-amphetamine)
• Phentermine (α,α-dimethylphenethylamine)
• Fenproporex
• Mefenorex
• Diethylpropion (primarily cathinone-like but often grouped here)

Ring-substituted amphetamines

• MDMA (3,4-methylenedioxymethamphetamine, “ecstasy”)
• MDA (3,4-methylenedioxyamphetamine)
• MDEA (3,4-methylenedioxyethylamphetamine)
• MBDB (N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine)
• 4-FA (4-fluoroamphetamine)
• 4-FMA (4-fluoromethamphetamine)
• 4-CA (4-chloroamphetamine)
• 4-CMC (4-chloromethcathinone – borderline cathinone/amphetamine)
• 2-FA, 2-FMA, 3-FA, 3-FMA

DOx series (2,5-dimethoxy-4-substituted amphetamines – highly potent hallucinogenic amphetamines)

• DOM (2,5-dimethoxy-4-methylamphetamine, “STP”)
• DOB (4-bromo-2,5-dimethoxyamphetamine)
• DOI (4-iodo-2,5-dimethoxyamphetamine)
• DOC (4-chloro-2,5-dimethoxyamphetamine)
• DOET, DON, DOPr, DOiPr, etc.

Other notable amphetamine derivatives

• PMA (4-methoxyamphetamine)
• PMMA (4-methoxymethamphetamine)
• 5-MAPB (5-(2-methylaminopropyl)benzofuran)
• 6-MAPB
• 5-MAPDiB
• Methiopropamine (MPA – thiophene analog)
• 3-MMC / 4-MMC (technically cathinones but frequently analyzed alongside amphetamines)

Legitimate scientific and analytical applications

Certified amphetamine reference standards are used for:

• Development and validation of immunoassays, GC-MS, LC-MS/MS, and HRMS methods
• Confirmation and enantioselective quantification in urine, blood, oral fluid, hair, and sweat
• Workplace drug testing, driving under the influence cases, and probation/parole monitoring
• Forensic analysis of seized materials (powders, tablets, capsules)
• Pharmacokinetic and metabolic studies (especially stereoselective metabolism of amphetamine and methamphetamine)
• Preparation of calibrators, quality control samples, and proficiency testing materials
• Stability studies (particularly important for substituted analogs in biological matrices)

Regulatory status and compliance requirements

The majority of amphetamines are strictly controlled:

• United States — Schedule II (pharmaceutical amphetamine, methamphetamine, lisdexamfetamine, phentermine); Schedule I (MDMA, MDA, DOB, DOM, PMA, most DOx compounds)
• Canada — Schedule I (most illicit amphetamines) or Schedule III (some pharmaceuticals)
• European Union — controlled under national laws; many ring-substituted and DOx compounds are listed or fall under NPS legislation
• United Kingdom — Class A (most potent hallucinogenic amphetamines, MDMA, MDA); Class B (amphetamine, methamphetamine)
• Australia, Japan, China, Russia — prohibited or heavily restricted

All products are supplied strictly for research, forensic, toxicological, and analytical purposes only. They are not intended for human or veterinary consumption, diagnostic use, therapeutic use, or any form of in-vivo administration. Customers must hold all required licenses, permits, and authorizations under applicable controlled substances regulations.

Quality standards for amphetamine reference materials

Reputable suppliers provide:

• Purity ≥98–99.9% (HPLC, qNMR)
• Full certificate of analysis including identity (NMR, HRMS, IR, UV), purity, and batch-specific data
• Isotopically labeled internal standards (e.g., amphetamine-d₅, methamphetamine-d₅, MDMA-d₅, MDA-d₅, PMA-d₄)
• Enantiomeric purity documentation (critical for d- vs l-amphetamine/methamphetamine differentiation)
• Positional isomer purity (especially for ring-substituted compounds)
• Recommended storage conditions (typically −20°C or −80°C, light and moisture protected)
• Stability data for parent compounds and metabolites

Commonly requested amphetamines in modern analytical laboratories

• d-Amphetamine
• Methamphetamine
• MDMA
• MDA
• MDEA
• 4-FA
• 4-FMA
• PMA
• PMMA
• DOM
• DOB
• DOI
• DOC
• Methiopropamine (MPA)
• 5-MAPB

Amphetamines constitute one of the most extensively studied and analytically significant classes of stimulants in forensic, clinical, and pharmaceutical chemistry. High-quality, well-characterized reference standards are essential for accurate identification, enantioselective quantification, metabolite detection, method validation, and supporting toxicology, workplace testing, and law enforcement efforts worldwide.

All materials in this category are provided exclusively for legitimate research and analytical purposes and must be handled in strict compliance with national and international controlled substances regulations.

Explore individual product pages for detailed specifications, certificates of analysis, safety data sheets, and current availability of each amphetamine reference standard.